Clinical Guideline & Protocol by John P. Troup, Ph.D.

Created by John P. Troup, Ph.D., Chief Science and Education Officer for Vital Nutrients, this clinical guide for practitioners provides product recommendations when working with patients to support a healthy balance of stress, mood, and resilient sleep. These guidelines address the underlying systems that influence the ‘connect-ome’ (microbiome, metabolome, neur-ome). This guide is intended to help address clinical issues of concern and provide the most appropriate dietary supplements and nutrition solutions.*

RegimenHealth ConcernClinical DescriptionAssessmentProduct OptionsRegimen
Occasional stress*Healthy balance to stress responses by HPA axis and gut diversity*Balance HPA system metabolic and endocrine control and responses and balance of the gut microbiome*Reset HPA axis for improved system response and balance; ensure gut microbiome diversity*Triple Mag
Tension Ease
Ultra Pure® Vegan Omega SPM+ 
Cortisol Balance 
B6 + B Complex – 
Fill nutrient gaps of Magnesium with Triple Mag; Balance gut microbiome with Hyperbiotics PRO-15.  Continue for 6 to 8 weeks.  Assess for positive response and if additional support needed introduce Cortisol Balance and Hyperbiotics PRO-Mood.
Elevated stress response*States of the stress response*Support reset and rebalance of the HPA system axis and gut microbiome*Assess impact of states of stress for advanced support*Cortisol Balance 
5HTP 50mg
L-Theanine 200mg
Provide foundational support with Cortisol Balance and Hyperbiotics PRO-Mood to reset the metabolome of the microbiome for 6 to 8 weeks. Assess need for additional support and address mood responses and add as necessary 5HTP and L-Theanine for 6 weeks and reassess.
Reproductive health hormone balance*Rebalance the metabolome and connect-ome* Stabilize metabolite and hormone connect-ome links*If stress is ongoing balance the HPA and HGA endocrine communications network*Cortisol Balance 
PRO-IBS Support* 
Whole Fiber Fusion
FertilAid for Men 
FertilAid for Women OR
FH PRO for Women
Continue to balance HPA axis for balanced cortisol for 12 weeks (and per above) and switch digestive support product to Hyperbiotics PRO-IBS Support* during this stage of care. Continue with 5HTP support and Fairhaven Health multivitamin with antioxidant support.
Poor quality of sleep pre-pregnancy*Support deep and restful sleep*Address cortisol recycling and balance*Support falling and staying asleep*L-Theanine 200mg Melatonin 3mg 
Cortisol Balance 
Sleep + Recover  – Coming Soon!
Using Cortisol Balance and Hyperbiotics PRO-Mood as foundational support, if quality sleep is an issue, start co-therapy with Sleep + Recover for 6 weeks and add Melatonin 3mg for 3 weeks.  If additional support needed, add L-Theanine to the regimen and 5HTP for an additional 3 to 6 weeks and reassess progress.
Lack of systems resiliency*Support immune and metabolic recovery systems and connect-ome network*Neuroendocrine system communications and balance*Balance cortisol response and neuro-endocrine communications that may have effects on reproductive health and system recovery*Ultra Pure® Vegan Omega SPM+ 
Cortisol Balance
Melatonin 10mg 
FH PRO for Women
Following 6 to 8 weeks of Cortisol Balance support with assessment of lack of resiliency, add Ultra Pure® Vegan Omega SPM+ and Melatonin for 6 more weeks and reassess.


High elemental magnesium formula offering 3 forms of magnesium for enhanced absorption.*

For relief of occasional stress and nervous tension.*

Supports healthy serotonin production.* 

Supports the body’s natural sleep cycle.*

Full-spectrum vegan formula supports adrenal function and cortisol balance for healthy energy, sleep, stress relief, and mood.*

Herbal and proteolytic enzyme support for a healthy inflammatory response in joints, sinus and digestive tract.* 

May help moderate occasional stress and promotes relaxation.* 

Supports the body’s natural sleep cycle.* 

A nutrient-dense vegan omega-3 dietary supplement providing 975mg of sustainably sourced, non-GMO, plant-based algal oil concentrate plus SPMs. 

Balanced B vitamin formula with extra B6 for menstrual cycle support.*  

Natural source of dietary fiber. 


Contains 15 Targeted Probiotic Strains plus Prebiotic to help support your gut, digestive, and immune health.* 

Comprehensive preconception health support supplement with a blend of herbs to promote hormone balance and cycle regularity.*

Formulated with 6 Targeted Probiotic Strains and L-theanine to help support healthy mood, stress response, memory, and focus.* 

A leading male fertility supplement since 2003, FertilAid for Men is formulated to support sperm count, motility, and morphology.* 

A powerful antioxidant-based fertility supplement that has been shown clinically to support sperm count, motility, and morphology.*  

Advanced dual-action combination formula specifically designed for people with IBS.*

Comprehensive fertility formula supporting hormone balance and egg health, includes a preconception multivitamin plus key antioxidants.*   

About Vital Nutrients

Vital Nutrients was founded nearly 30 years ago by practitioners who set out to make a positive impact on the health of people and the planet. The company produces a comprehensive portfolio of premium quality, clean supplements at its allergen-free, NSF-certified manufacturing facility in Middletown, Connecticut. Vital Nutrients’ clinically relevant, clean-label formulas are trusted and beloved by healthcare practitioners and health-conscious consumers worldwide. Vital Nutrients’ long-standing reputation for efficacy-first in formulation and manufacturing is anchored to a rigorous quality assurance program. It includes testing raw ingredients and finished products via 3rd party independent laboratories to ensure purity and potency in every capsule.

Vital Nutrients is part of the Blueroot health family of brands and is championing sustainability, determined to do right by their employees, partners, and communities.

About Blueroot Health

Blueroot Health™ is a consumer health company growing a diverse portfolio of brands that fuel lasting happiness and health for people and planet. The company’s industry-leading brands – including Vital Nutrients®Bariatric Fusion®,  Fairhaven Health® and Hyperbiotics® – offer a suite of clean, innovative, and clinically relevant nutritional supplements that work. The portfolio includes specialized solutions for fertility and reproductive health, metabolic and bariatric health, and precision probiotics, as well as a full spectrum of clinically relevant formulas trusted by healthcare practitioners, patients and consumers worldwide. Blueroot Health is committed to making a lasting, positive impact on the communities it serves, without leaving a negative footprint on the planet.